To Phase 3 or Not to Phase 3?

To phase 3 or not to phase 3?

See related article, pages 1803–1810. D ecisions to progress new chemical entities, biologicals, or new treatment modalities into Phase 3 are usually based on small Phase 2 studies that are designed to assess safety and to explore efficacy. 1–3 Based on these Phase 2 safety studies, both large and small companies have launched large Phase 3 programs that include 2 concurrently run studies, ie, ...

to be or not to be that’s the question-3

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Robust Fuzzy Gain-Scheduled Control of the 3-Phase IPMSM

This article presents a fuzzy robust Mixed - Sensitivity Gain - Scheduled H controller based on the Loop -Shaping methodology for a class of MIMO uncertain nonlinear Time - Varying systems. In order to design this controller, the nonlinear parameter - dependent plant is first modeled as a set of linear subsystems by Takagi and Sugeno’s (T - S) fuzzy approach. Both Loop - Shaping methodology and...

Folic Acid Supplementation: to Advise or not to Advise?

Analytical Solutions to 3-D Bioheat Transfer Problems with or without Phase Change

Theoretical analysis on the bioheat transfer process has been an extremely important issue in a wide variety of bioengineering situations such as cancer hyperthermia, burn injury evaluation, brain hypothermia, disease diagnostics, thermal comfort analysis, cryosurgery and cryopreservation etc. In this chapter, the theoretical strategies towards exactly solving the three-dimensional (3-D) biohea...